Catalogue Number: 28017-IBL
|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|
|Type:||Polyclonal Primary Antibody - Unconjugated|
|Shipping Condition:||Blue Ice|
|Unit(s):||100 ug, 10 ug|
|Immunogen:||The synthetic peptide of a part of Human TSC1/Hamartin (GQLHIMDYNETHHEHS)|
Description: TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin, a product of another tumor-suppressor gene TSC2 in cytoplasm. The complex suppresses mTOR activity and regulates cellular growth and division in a insulin signaling pathway. Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division.