Anti-Human TSC1/Hamartin (T1149) Rabbit IgG Affinity Purify

Catalogue Number: 28017-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Unit(s): 100 ug, 10 ug
Host name:
Clone:
Isotype:
Immunogen: The synthetic peptide of a part of Human TSC1/Hamartin (GQLHIMDYNETHHEHS)

Description

Description: TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin, a product of another tumor-suppressor gene TSC2 in cytoplasm. The complex suppresses mTOR activity and regulates cellular growth and division in a insulin signaling pathway. Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division.

Additional Text

Specificity

Cross reacts with mouse

Price
280.00


Find out about delivery

SUPPORT

outstanding technical support

PRODUCT

we offer a full product guarantee

DELIVERY

we offer free delivery to UK universities and non profit organisations