Anti-Human TSC1/Hamartin (T1149) Rabbit IgG Affinity Purify

Catalogue Number: 28017-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 10 ug
Host name: Rabbit
Isotype: IgG
Immunogen: The synthetic peptide of a part of Human TSC1/Hamartin (GQLHIMDYNETHHEHS)
Application: WB, IHC


Description: TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin, a product of another tumor-suppressor gene TSC2 in cytoplasm. The complex suppresses mTOR activity and regulates cellular growth and division in a insulin signaling pathway. Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division.


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