Anti-Human PRAS40 (S183 Phosphorylated) Rabbit IgG Affinity Purify 28035
Catalogue Number: 28035-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 10 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide of the phosphorylated part of Human PRAS40 (QYAK(pS)LPVS) |
| Application: | WB |
Description
Description: mTOR exists as two types of complexes called mTORC1 and mTORC2. mTORC1 is regulated in activity by amino acid and inhibited specifically by a immunosuppressant "rapamycin". It is considered that PRAS40 is phosphorylated by mTORC1, for phosphorylation of PRAS40 (proline-rich Akt substrate of 40 kDa) which is a novel substrate of mTOR at Ser-183 (human) is induced by amino-acid stimulation and inhibited by rapamycin. It is known that mTORC1 is inhibited by AMP kinase system and then phosphorylation of PRAS40 at Ser-183 is inhibited by 2-Deoxyglucose (2DG) treatment inducing activation of AMP-kinase. It is shown that PRAS40 is dissociated from raptor which is a component of mTORC1 when it is phosphorylated by mTORC1, and it is assumed that phosphorylation of PRAS40 at Ser-183 is involved in controlling mTOR signal-transducing pathway. This antibody recognizes the phosphorylation of PRAS40 at Ser-183 (human).
Additional Text
Purification
Affinity Purified
Modification
Phosphorylated, Ser183
Antibody Clonality
Polyclonal
28035 Datasheet
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