Anti-Human Gastrin Receptor (OK-524) Rabbit IgG Affinity Purify 28103
Catalogue Number: 28103-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 10 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide of the C terminal part of Human Gastrin Receptor(CTPSIASLSRLSYTTIS) |
| Application: | WB, IHC |
Description
Description: Gastrin is one of the most important gut-related hormones contributing to gastric acid secretion. Gastrin and the gastrin receptor (GR) are coexpressed in many gastrointestinal cancer cell lines, and gastrin is regarded as an autocrine growth factor for these cells. Thus, gastrin is important in the investigation of gastrointestinal carcinogenesis and anticancer therapy. The GR (identical with the cholecystokinin B receptor; CCKBR ) gene was cloned by Lee et al. and has an open reading frame encoding 447 amino acids with 7 transmembrane domains. To date, many studies have revealed the localization of GR in the human stomach. It has been of public interest to investigate the expression and potential role of gastrin and GR in gastric carcinogenesis and their relation to Helicobacter pylori infection and inflammation.
Additional Text
Purification
Affinity Purified
Antibody Clonality
Polyclonal
28103 Datasheet
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