Anti-OPRT Rabbit IgG Affinity Purify 28135
Catalogue Number: 28135-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 10 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide of a part of Human OPRT(ISAADRLEAAEMYRKAAWEAY: 454-474) |
| Application: | WB, IHC |
Description
Description: Thymidylate synthase/TS (EC 2.1.1.45), Dihydropyrimidine degydrogenase/DPD (EC 1.3.1.2), Thymidene phosphorylase/TP (EC 2.4.2.4) and Orate phosphorybosyl transferase/OPRT (EC 2.4.2.10) are known as key enzymes related to nucleic-acid metabolism within the body. These enzymes are also known to be related to activation, metabolism and catabolism of 5-FU (5-fluorouracil) which is a metabolic antagonist being widely used for solid cancers including digestive system cancer and breast cancer as an anticancer drug. And there are some reports regarding correlation between the enzymes and the effects of 5-FU-based anticancer drugs. Additionally, TS and DPD have been reported to be prognostification-related factors of individuals who suffer cancers. As seen above, this antibody is useful for researches of nucleic acid and expression of those proteins in cancer tissues including effect prediction of 5-FU-based anticancer drugs and searching for prognostification factors.
Additional Text
Purification
Affinity Purified
Antibody Clonality
Polyclonal
28135 Datasheet
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