Catalogue Number: 28143-IBL
|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|
|Physical state:||Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3|
|Type:||Polyclonal Primary Antibody - Unconjugated|
|Shipping Condition:||Blue Ice|
|Unit(s):||50 ug, 5 ug|
|Immunogen:||Synthetic peptide of the phosphorylated part of Human Girdin (KDSNP(pY)ATLPRAS)|
Description: Girdin is a new protein playing an important role in the infiltration and metastasis of cancer cells. A new substance of Akt, Girdin (Girders of actin filament) was discovered by a research group led by Takahashi et al., Nagoya University by screening using yeast two-hybrid method and was elucidated that Girdin has an important role for cell migration downstream of Akt.
It has been proven that Girdin is a new actin binding protein and it restructures actin fibers upon it is phosphorylated by Akt and it involves in forming of lamellipodia that is located at the leading edge of cells and playing an important roles for cell migration by functional analysis. Various antibodies inclusive phosphorylated Girdin antibodies are provided by IBL and it has been suggested that the change of condition of phosphorylated Girdin involves in structure alteration in relation to cell migration in vivo or in vitro by current studies used these antibodies.
Cross-react with Human and Mouse Phosphorylated Girdin