Anti-Human MDA5 IgG Affinity Purify

Catalogue Number: 29020-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name:
Clone:
Isotype:
Immunogen: Synthetic peptide of part of N terminal of human MDA5 (TIEDRNRIAAAENNGN)

Description

Description: A full-length cDNA encoding MDA5 was isolated by screening a melanoma differentiation-subtracted library and a placenta cDNA library, also known as Ifih1(Interferon induced with helicase C domain protein 1). Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA. Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database. MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses.

Additional Text

Specificity

Reacts with human and mouse MDA5