Anti-GRAP2/GADS Monoclonal Antibody (Clone:UW40)
Catalogue Number: 30-1448-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | GRAP2||GADS||GRB2L||GRID |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Mouse |
| Clone: | UW40 |
| Isotype: | IgG2a |
| Immunogen: | GST-fusion human GRAP2/GADS protein |
| Application: | FACS, IP, WB |
Description
Description: GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
Additional Text
Gene ID
9402
Gene Name
GRAP2
Uniprot ID
O75791
Purification
Protein A purified
Antibody Clonality
Monoclonal
Application Notes
Flow Cytometry Recommended dilution:1 µg/ml Immunoprecipitation Western Blotting
30-1448 Datasheet
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