Anti-LARGE1 Monoclonal Antibody (Clone:LARGE-02)
Catalogue Number: 30-1504-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | LARGE1||KIAA0609||LARGE |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Mouse |
| Clone: | LARGE-02 |
| Isotype: | IgG2b |
| Immunogen: | Recombinant fragment of human LARGE1 (amino acids 35-142) |
| Application: | FACS, WB |
Description
Description: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
Additional Text
Uniprot ID
O95461
Gene ID
9215
Purification
Protein A purified
Gene Name
LARGE1
Antibody Clonality
Monoclonal
30-1504 Datasheet
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