PE Conjugated Anti-PCLO Monoclonal Antibody (Clone:PCLO-01)
Catalogue Number: 30-2342-ABO
30-2342 Image
30-2342 Image
Fig. 1: Western blot of human REH erythroid cell line lysate (1% laurylmaltoside); non-reduced sample, immunostained by mAb PCLO-01 and goat anti-mouse IgG (H+L)-HRP conjugate. The zone evidently corresponds to a small splice variant of the PCLO protein present in this type of cell (see Uniprot database, Genome Res. 14:2121-2127(2004)); the major form (over 500 kDa) expressed in neurons is too large for analysis by Western blotting.
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | PCLO||ACZ||KIAA0559 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Mouse |
| Clone: | PCLO-01 |
| Isotype: | IgG1 |
| Immunogen: | Human recombinant PCLO protein |
| Application: | FACS |
Description
Description: PCLO (piccolo, also known as aczonin) is a large (more than 400 kDa) multidomain protein of the presynaptic cytomatrix in neurons, that is present in all vertebrate synapses, but is absent from invertebrates. It contains zinc finger and coiled-coil sequences, as well as N-terminal glutamine-rich sequence, and C-terminal PDZ domain followed by two C2 domains (C2A and C2B). In vitro binding and transfection experiments suggested that PCLO binds to multiple proteins including profilin and L-type calcium channels. It is involved in neurotransmitter release and insulin secretion.
Additional Text
Gene ID
27445
Gene Name
Pclo
Antibody Clonality
Monoclonal
UniProt ID
Q9Y6V0
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