Anti-CD25 / IL-2R alpha chain Monoclonal Antibody (Clone:MEM-181)-PE/DyLight Conjugated
Catalogue Number: 30-2463-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | IL2RA |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests |
| Host name: | Mouse |
| Clone: | MEM-181 |
| Isotype: | IgG1 |
| Immunogen: | PHA-activated peripheral blood leucocytes |
| Application: | FACS |
Description
Description: CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas.
Additional Text
Gene Name
IL2RA
Gene ID
3559
Uniprot ID
P01589
Antibody Clonality
Monoclonal
30-2463 Datasheet
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