Catalogue Number: 30-2466-ABO
Manufacturer: | Abeomics |
Type: | Monoclonal Primary Antibody - Unconjugated |
Alias: | PECAM1 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 tests |
Host name: | Mouse |
Clone: | MEM-05 |
Isotype: | IgG1 |
Immunogen: | Leukocytes of patient suffering from LGL-type leukaemia |
Application: | FACS |
Description: CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
PECAM1
5175
P16284
Monoclonal