Anti-GRAP2 APC (Clone : UW40)
Catalogue Number: 30-2528-ABO
30-2528 Image
30-2528 Image
30-2528 Image
Figure 1 : Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human GRAP2(UW40) APC antibody (concentration in sample 1,7 µg/ml).
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Figure 2 : Separation of lymphocytes stained using anti-human GRAP2 (UW40) APC antibody (concentration in sample 1,7 µg/ml, red-filled) from lymphocytes stained using mouse IgG2a isotype control (MOPC-173) APC antibody (concentration in sample 1,7 µg/ml, same as GRAP2 APC concentration, black-dashed) in flow cytometry analysis (intracellular staining) of peripheral blood.
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | GADS, GRID, GRAP-2, GrbX,GRB2 related adaptor protein 2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | |
| Clone: | UW40 |
| Isotype: | IgG2a |
| Immunogen: | GST-fusion human GRAP2/GADS protein |
| Application: | FACS |
Description
Description: GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.Specificity : The mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
Additional Text
Gene ID
9402
Gene Name
GRAP2
Purification
Purified
Antibody Clonality
Monoclonal
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