Substance P (Substance P, Tachykinin, Neuropeptide, Neurokinin, SP)
Catalogue Number: 301768-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a lyophilized powder in 0.05% thimerosal. Reconstitute with 500ul ddH2O. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ul |
| Host name: | Rat |
| Clone: | NC1/34 |
| Isotype: | IgG2a |
| Immunogen: | Substance P |
| Application: | ELISA, ICC, IHC |
Description
Description: The discovery of substance P (SP) was reported in 1931. After more than 70 years of investigation, SP is perhaps the best understood neuropeptide transmitter. Substance P is an undecapeptide, which by the mid-1980s was recognized to belong to the tachykinin peptide family; it is also member of the neurokinins. It has been proposed that SP, released from primary afferent nerve endings, plays a role in chronic inflammation and pain. Neurotransmitters appear to play a key role in the regulation of emotions and antagonists of their receptors may be novel psychotropic drugs of the future.
Additional Text
Gene Name
TAC1
Gene ID
6863
Uniprot ID
P20366
Specificity
Recognizes the COOH-terminal end of Substance P. Recognizes Substance P in post-mortem tissue of the human brain. Does not recognize Leu- or Met enkephalin, somatostatin or beta-endorphin. Cross reacts with eledoisin (5%). Species Crossreactivity: all mammalian species, crab, pigeon, human.
Antibody Clonality
Monoclonal
301768 Datasheet
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