HIV-1, C2 (gp120)
Catalogue Number: 301814-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a lyophilized powder in PBS. Reconstitute with 100ul ddH2O. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Human |
| Clone: | 1006-30 |
| Isotype: | IgG1 |
| Immunogen: | HIV-infected individuals using a method based on the Epstein-Barr virus transformation of peripheral blood mononuclear cells (PBMCs) followed by fusion with heteromyeloma cells. |
| Application: | ELISA |
Description
Description: Of the two types of Human immunodeficiency virus (HIV) which have been characterized, HIV-1 is more infective and is prevalent globally. The HIV virion is encapsulated by a viral envelope that contains complexes of surface proteins, which are important for the virus to attach and fuse to infect target cells. A precursor molecule known as gp160 (glycoprotein 160) is cleaved by proteases into gp120 (glycoprotein 120) and gp41 (glycoprotein 41), glycoproteins that make up the envelope proteins of HIV. The gp120 protein is composed of five variable regions (V1-V5) which often form loop structures, and five constant regions (C1-C5). Some evidence suggests that the C2 region is implicated in the oligomerization of gp120.
Additional Text
Specificity
Recognizes the C2 region of the HIV-1 protein gp120, aa241-260.
Purification
Protein G purified
Antibody Clonality
Monoclonal
301814 Datasheet
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