Activin A Plant-Active Recombinant Protein
Catalogue Number: 32-1002-ABO
| Manufacturer: | Abeomics |
| Type: | Other Recombinant Protein |
| Alias: | Inhba||Inhibin beta A||FSH releasing protein. |
| Shipping Condition: | Blue Ice |
| Unit(s): | 5 ug |
Description
Description: Source : Nicotiana benthamiana. Active form Activin-A Human Recombinant produced in Plant is a homodimeric, glycosylated, polypeptide chain containing 2 x 116 amino acids & having a molecular weight of 27.4kDa.The Active form Activin-A is fused to a 6-His tag at N-terminus & purified by st&ard chromatographic techniques. Activins are homodimers or heterodimers of the different Beta subunit isoforms, part of the TGF Beta family. Mature Activin A has two 116 amino acids residues BetaA subunits ( BetaA- BetaA). Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, & reproductive physiology. Activins takes part in the production & regulation of hormones such as FSH, LH, GnRH & ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, & ovarian granulosa cells.
Additional Text
Application Notes
INHBA protein should be reconstituted in distilled water to a concentration of 50 ug /ml. Due to the protein nature, dimmers & multimers may be observed. The biological activity of INHBA is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation ([3H]thymidine incorporation). ED50<5ng/ml.
32-1002 Datasheet
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