EPO a Fc Recombinant Protein
Catalogue Number: 32-1152-ABO
| Manufacturer: | Abeomics |
| Type: | Other Recombinant Protein |
| Alias: | EPO-a||EPO-alpha||Epoetin||EP||MGC138142. |
| Host Cell: | CHO |
| Shipping Condition: | RT |
| Unit(s): | 10 ug |
Description
Description: Source : Chinese Hamster Ovary Cells(CHO). Erythropoietin-alpha Fc-Chimera Human Recombinant is produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology is a dimeric, glycosilated, polypeptide chain consisting of two mature human EPO molecules linked to the Fc portion of human IgG1. The Fc component contains the CH2 domain, the CH3 domain & hinge region, but not the CH1 domain of IgG1. As a result of glycosylation, the recombinant protein migrates with an apparent molecular mass of 140 kDa in non-reducing SDS-PAGE. This gene is a member of the EPO/TPO family & encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma & regulates red cell production by promoting erythroid differentiation & initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries & antiapoptotic functions in several tissue types.
Additional Text
Protein Tag
Fc Tag
Application Notes
It is recommended to reconstitute the lyophilized Erythropoietin in sterile 18MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. The ED50 as determined by the dose-dependent stimulation of human megakaryoblastic leukemia cells is less than 2.0 ng/ml, corresponding to a Specific Activity of 5.0 x 105 IU/mg.
32-1152 Datasheet
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