PDGF AA Yeast Recombinant Protein
Catalogue Number: 32-1653-ABO
| Manufacturer: | Abeomics |
| Type: | Other Recombinant Protein |
| Alias: | Glioma-derived growth factor||GDGF||Osteosarcoma-derived Growth Factor||ODGF||PDGF-AA||PDGF-1. |
| Host Cell: | Pichia pastoris |
| Shipping Condition: | RT |
| Unit(s): | 10 ug |
Description
Description: Source : Pichia Pastoris. PDGF-AA Human Recombinant produced in Yeast is a homodimeric, glycosilated, polypeptide chain containing 2 x 110 amino acids & having a total molecular mass of 34 kDa. PDGF-AA is purified by proprietary chromatographic techniques. PDGF-AA, PDGF-BB & PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone & cartilage cells, & some blood cells. The PDGF is stored in platelet alpha-granules & released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, & respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified & named PDGFR-alpha & PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other h&, PDGFR-beta interacts with only PDGF-BB & PDGF-AB.
Additional Text
Application Notes
It is recommended to reconstitute the lyophilized PDGF-AA in sterile 18MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. The ED50 was found to be 1ng/ml corresponding to a Specific Activity of 1,000,000IU/mg calculated by the ability to stimulate the proliferation of mouse 3T3 fibroblasts (PNAS 94, 10205, 1997. Biochemistry, 1996, 35, 12077).
32-1653 Datasheet
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