Platelet factor-4 Native Protein
Catalogue Number: 32-1978-ABO
| Manufacturer: | Abeomics |
| Type: | Other Native Protein |
| Alias: | CXCL4||PF-4||PF4||Iroplact||Oncostatin-A||SCYB4||MGC138298. |
| Shipping Condition: | Blue Ice |
| Unit(s): | 20 ug |
Description
Description: Source : Human Platelets. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets & binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity & promoting coagulation. As a strong chemoattractant for neutrophils & fibroblasts, PF4 probably has a role in inflammation & wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
Additional Text
Application Notes
It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
32-1978 Datasheet
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