Alpha Actinin Native Protein
Catalogue Number: 32-3176-ABO
| Manufacturer: | Abeomics |
| Type: | Other Native Protein |
| Alias: | Alpha-actinin-1||Alpha-actinin cytoskeletal isoform||Non-muscle alpha-actinin-1||F-actin cross-linking protein||ACTN1. |
| Host Cell: | Chicken gizzard |
| Shipping Condition: | RT |
| Unit(s): | 50 ug |
Description
Description: Source : Chicken Gizzard. Ultra pure Alpha Actinin having a Molecular mass of 95,000 Dalton. ACTN1 encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Additional Text
Application Notes
It is recommended to reconstitute the lyophilized a-Actinin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
32-3176 Datasheet
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