Recombinant Cavia porcellus CTLA-4 (C-6His)
Catalogue Number: 32-8376-ABO
| Manufacturer: | Abeomics |
| Shelf Life: | 6 months |
| Type: | Fusion Protein |
| Shipping Condition: | Dry Ice |
| Unit(s): | 10 ug, 50 ug |
Description
Description: Source: P.Pichia. MW :14.1kD. Recombinant Cavia porcellus Cytotoxic T-lymphocyte protein 4 is produced by our Yeast expression system and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus. Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Additional Text
Gene Name
CTLA4
Uniprot ID
H0VUB1
Application Notes
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Gene ID
100725760
Protein Tag
6xHIS Tag
32-8376 Datasheet
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