Polyclonal Antibody to 4E-BP1 (Phospho-Thr45)
Catalogue Number: 35-1209-ABO
35-1209 Image
35-1209 Image
35-1209 Image
Figure 1: Western blot analysis of extracts from Hela cells using 4E-BP1(Phospho-Thr45) Antibody 35-1209 and the same antibody preincubated with blocking peptide.
35-1209 Image
Figure 2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 4E-BP1(Phospho-Thr45) Antibody 35-1209 (left) or the same antibody preincubated with blocking peptide(right).
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | EIF4EBP1|| PHAS-1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Peptide sequence around phosphorylation site of threonine 45 (S-T-T(p)-P-G) derived from Human 4E-BP1. |
| Application: | WB, IHC |
Description
Description: 4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a imiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Gingras AC, et al. (1998) Genes Dev 12(4): 502-513. Brugarolas J, et al. (2004) Genes Dev 18(23): 2893-2904. Kumar V, et al. (2000) EMBO J 19(5): 1087-1097. Moody CA, et al. (2005) J Virol 79(9): 5499-5506. Burnett PE, et al. (1998) Proc Natl Acad Sci U S A 95(4): 1432-1437.
Additional Text
Gene ID
1978
Gene Name
EIF4EBP1
Uniprot ID
Q13541
Antibody Clonality
Polyclonal
Application Notes
Predicted MW: 18kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
35-1209 Datasheet
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