Catalogue Number: 35-1731-ABO
Manufacturer: | Abeomics |
Type: | Polyclonal Primary Antibody - Unconjugated |
Alias: | HD4/HD5/HD9 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 ug, 50 ug |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | Peptide sequence around aa.244~248/257~261/218~222 (T-A-S-E-P) derived from Human HDAC4/HDAC5/HDAC9. |
Application: | IF, WB, IHC |
Description: Responsible for the deacetylation of ysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of arge multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16. Vigushin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218. Marmorstein, R. (2001) Cell Mol ife Sci 58, 693-703. Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.
9759
HDAC4
P56524
Polyclonal
Predicted MW: 140 124 111 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200