HMGB1 (High Mobility Group Box-1)
Catalogue Number: 353417-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Hamster |
| Clone: | 5H6 |
| Isotype: | IgG |
| Immunogen: | Recombinant protein corresponding to HMGB1. |
| Application: | FC, IF, WB |
Description
Description: HMGB1 (High Mobility Group Box-1 protein also known as amphoterin) is a highly conserved protein with more than 95% aa identity between rodent and human HMGB1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMGB1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMGB1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMGB1, identified as a membrane associated protein termed "amphoterin," mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice.
Additional Text
Specificity
Recognizes mouse HMGB1. Species Crossreactivity: human, rat
Purification
Protein G purified
Antibody Clonality
Monoclonal
353417 Datasheet
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