CD3 epsilon (T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain CD_antigen, CD3e) (Chimeric)
Catalogue Number: 361541-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | UCHT1 (recomb) |
| Isotype: | IgG1, kappa |
| Immunogen: | Human infant thymocytes |
| Application: | FC, IHC |
Description
Description: Recombinant monoclonal antibody to CD3 epsilon with variable regions (i.e., specificity) from the hybridoma UCHT1. This chimeric human antibody was made using the variable domain sequences of the original mouse IgG1 format. Manufactured using a proprietary recombinant platform technology. CD3, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging from 16-28kD and is closely associated with the T cell antigen receptor (TCR). CD3 is expressed on 70-80% of normal peripheral blood lymphocytes and on 10-20% of thymocytes. It plays a major role in signaling during antigen recognition, leading to T cell activation.
Additional Text
Gene Name
CD3E
Gene ID
916
Uniprot ID
P07766
Specificity
Recognizes epitopes on CD3-epsilon found in heterodimers with CD3-delta and with CD3-gamma of alpha/beta T cell receptor (TCR).
Purification
Protein A purified
Antibody Clonality
Recombinant Monoclonal
361541 Datasheet
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