CD40L (CD40 Ligand, Tumor Necrosis Factor Ligand Superfamily Member 5, TNFSF5, CD154, Tumor Necrosis Factor Related Activation Protein, TRAP)

Catalogue Number: 361563-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300.
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	CD154\|CD40 antigen ligand\|CD40 ligand\|CD40L\|CD40-L\|gp39\|hCD40L\|HIGM1\|IGM\|IMD3\|T-B cell-activating molecule\|T-BAM\|T-cell antigen Gp39\|TNF-related activation protein\|TNFSF5\|TRAP\|tumor necrosis factor (ligand) superfamily member 5
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Human
Clone:	hu5c8 (Ruplizumab) (recomb)
Isotype:	IgG1, kappa
Immunogen:	Human CD40L
Application:	FC, WB

Overview
Datasheets

Description

Description: Recombinant monoclonal antibody to CD40L with variable regions (i.e. specificity) from the original hybridoma hu5c8 (Ruplizumab). Manufactured using a proprietary recombinant platform technology. Not for therapeutic use; this is a research grade biosimilar. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531+/-155 hours.

Additional Text

Uniprot ID

P29965

Gene Name

CD40LG

Gene ID

959

Specificity

Recognizes human CD40L. Binds to CD40L with an IC50 of 0.845ug/ml.

Purification

Protein A purified

Antibody Clonality

Recombinant Monoclonal

361563 Datasheet

Price

£846.00

-

Quantity
Unit Size

Find out about delivery