ErbB2 (Her-2/Neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, p185erbB2, p185HER2)
Catalogue Number: 361584-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | 4D5-8 (trastuzumab) (recomb) |
| Isotype: | IgG1, kappa |
| Immunogen: | A431 cells (human epidermoid carcinoma) (over)expressing EGFR. |
| Application: | ELISA, FC, IHC |
Description
Description: Recombinant monoclonal antibody to ErbB2 with variable regions (i.e. specificity) from the therapeutic antibody 4D5-8 (trastuzumab). Manufactured using a proprietary recombinant platform technology. Not for therapeutic use; this is a research grade biosimilar. Oncogenic protein Her-2/neu (erbB-2), is a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder. This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC.
Additional Text
Gene ID
2064
Gene Name
ERBB2
Uniprot ID
P04626
Specificity
Recognizes ErbB-2. Species Crossreactivity: human
Purification
Protein A purified
Antibody Clonality
Recombinant Monoclonal
361584 Datasheet
SUPPORT
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PRODUCT
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