CD278 (Inducible T-Cell Costimulator, ICOS, Activation-inducible Lymphocyte Immunomediatory Molecule, CCLP, CD278, CD28 and CTLA-4-like Protein, CD28-related Protein 1, CRP-1, H4)

Catalogue Number: 366934-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS. No preservative added.
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	activation-inducible lymphocyte immunomediatory molecule\|AILIM\|CCLP\|CD28 and CTLA-4-like protein\|CD28-related protein 1\|CRP-1\|H4\|inducible T-cell costimulator\|Ly115
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Hamster
Clone:	C398.4A
Isotype:	IgG
Immunogen:	D10.G4.1 mouse TH2 cells. Epitope: Extracellular domain. Species sequence homology: rhesus macque.
Application:	FC, ICC, IP, IHC

Overview
Datasheets

Description

Description: Inducible T-cell costimulator (UniProt Q9WVS0; also known as Activation-inducible lymphocyte immunomediatory molecule, CCLP, CD278, CD28 and CTLA-4-like protein, CD28-related protein 1, CRP-1, H4) is encoded by the Icos (also known as Ailim) gene (Gene ID 54167) in murine species. ICOS is a costimulatory molecule expressed on activated T cells and regulatory T cells, it plays a crucial role in T-cell survival and function, Th2 cell differentiation, and lung inflammatory responses. Upon ICOS-ligand (ICOS-L) binding, ICOS initiates a cascade of intracellular signaling events, leading to the production of cytokines such as IL-4 and IL-13. Both ICOS and ICOS-L are expressed on type 2 innate lymphoid cells (ILC2s) that, along with Th2 cells, contribute to the pathogenesis of asthma by producing copious amounts of IL-5 and IL-13. ICOS and ICOS-L interaction is reported to promote cytokine production and survival of ILC2s through STAT5 signaling. ICOS-deficiency or blocking ICOS and ICOS-L interaction is shown to prevent cytokine-induced asthma and lung inflammation in a humanized murine model with adoptively transferred human peripheral ILC2s. Human and murine ICOS proteins are produced with a signal peptide (aa1-20) sequence, which is removed posttranslationally to yield the mature protein with a large N-terminal extracellular (human aa21-140 and murine aa21-144) region composed almost entirely of a V-type Ig-like domain (human aa30-132 and murine aa30-133), followed by a transmembrane domain (human aa141-161 and murine aa145-165) and a cytoplasmic tail (human aa162-199 and murine aa166-200).

Additional Text

Gene Name

ICOS

Accession Number

NP_059508

Specificity

Recognizes mouse ICOS/CD278. Species Crossreactivity: human

Purification

Protein G purified

Uniprot ID

Q9WVS0

Gene ID

54167

Antibody Clonality

Monoclonal

366934 Datasheet

Price

£786.00

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