Zika Virus NS1 (Zika Virus Nonstructural Protein 1)

Catalogue Number: 367955-USB

Manufacturer:	United States Biological
Physical state:	Supplied as liquid in 0.015M potassium phosphate, pH 7.2, 0.85% sodium chloride, 0.05% sodium azide.
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	500 ug
Host name:	Mouse
Clone:	16k362
Isotype:	IgG1, kappa
Immunogen:	Recombinant protein corresponding to Zika Virus NS1.
Application:	ELISA, LF

Overview
Datasheets

Description

Description: Zika virus (ZIKV), a Flaviviridae family member transmitted to humans by mosquitoes of the genus Aedes, was first isolated in Africa in 1947. It has been found to commonly circulate in tropical regions in Africa and Asia. As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-translationally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). NS1 is required for viral replication inside cells and is also secreted into the extracellular space as a hexameric lipoprotein particle, which is involved in immune evasion and pathogenesis by interacting with components from both the innate and adaptive immune systems. Many people infected with Zika virus will have mild or no symptoms while others will have fever, rash, joint pain, or conjunctivitis. People rarely die from Zika virus. Pregnant woman can pass Zika virus to her fetus causing microcephaly and other severe fetal brain defects.

Additional Text

Specificity

Recognizes Zika Virus NS1. No cross reactivity with recombinant Dengue and Chikungunya antigens.

Purification

Ion Exchange

Antibody Clonality

Monoclonal

367955 Datasheet

Price

£826.00

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Quantity
Unit Size

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