iFluor® 750 RGD Conjugate
Catalogue Number: 36800-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 24 months |
| Type: | Probes |
| Shipping Condition: | RT |
| Unit(s): | 1 mg |
Description
Description: Near-infrared fluorescence optical imaging (also called in vivo Imaging) is emerging as a powerful technology for studying diseases at molecular level in small animal models. Water and biological tissues have minimal absorbance and autofluorescence in the NIR window (650−900 nm), thus allowing efficient photon penetration into, and out of tissue with low intra-tissue scattering. Across this NIR window, light absorption by physiologically abundant molecules such as hemoglobin, oxyhemoglobin and deoxyhemoglobin is also reduced to a minimum. In vivo imaging systems with biocompatible fluorescence agents are being developed and optimized for use in the near infrared spectral region - ensuring maximum light penetration and highest sensitivity. The cell adhesion molecule integrin is involved in angiogenesis and metastasis in many tumor types. Integrin is significantly up-regulated in activated endothelial cells and fast-growing solid tumor cells, compared to its minimum expression in quiescent blood vessels and most normal tissues. iFluor™ 750-labeled monomeric arginine-glycine-aspartic acid (RGD) peptide c(RGDyK) specifically targets integrin both in cell culture and in living subjects. The in vivo efficacy of iFluor™ 750-c(RGDyK) depends on many factors, including the receptor affinity, specificity, molecular size, overall molecular charge, hydrophilicity and metabolic stability.
Additional Text
Storage Note
Freeze (< -15 °C); Minimize light exposure;|24 months
36800 Protocol
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