CD40L (CD40 Ligand, CD154, Tumor Necrosis Factor Ligand Superfamily Member 5, TNFSF5, Gp39, TRAP)

Catalogue Number: 368506-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS. No preservative added.
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	CD154\|CD40 antigen ligand\|CD40 ligand\|CD40L\|CD40-L\|gp39\|hCD40L\|HIGM1\|IGM\|IMD3\|T-B cell-activating molecule\|T-BAM\|T-cell antigen Gp39\|TNF-related activation protein\|TNFSF5\|TRAP\|tumor necrosis factor (ligand) superfamily member 5
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Human
Clone:	hu5c8
Isotype:	IgG1, kappa
Immunogen:	Recombinant protein corresponding to human CD40L
Application:	FC, WB

Overview
Datasheets

Description

Description: CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kD type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

Additional Text

Uniprot ID

P29965

Gene Name

CD40LG

Gene ID

959

Specificity

Recognizes and binds human CD40L with an IC50 of 0.845ug/ml. Species Crossreactivity: canine

Purification

Protein A purified

Antibody Clonality

Monoclonal

368506 Datasheet

Price

£581.00

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Quantity
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