Alpha Synuclein (Alpha Synuclein, Non-A Beta Component Of AD Amyloid, Non-A4 Component Of Amyloid Precursor, NACP, SNCA, PARK1, PARK 1, AlphaSYN, PARK 4, PARK4, Parkinson Disease Familial 1, Parkinson Disease (Autosomal Dominant, Lewy body) 4, SYN)

Catalogue Number: 384968-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	alphaSYN\|alpha-Syn\|alpha-synuclein\|NACP\|non-A beta component of AD amyloid\|non-A4 component of amyloid
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	4F1
Isotype:	IgG1
Immunogen:	Mouse alpha synuclein aggregate.
Application:	ELISA, ICC, IF, WB, DB, IHC

Overview
Datasheets

Description

Description: Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

Additional Text

Gene Name

SNCA

Gene ID

20617

Purification

Protein G purified

Accession Number

NP_001035916.1

Uniprot ID

O55042

Antibody Clonality

Monoclonal

384968 Datasheet

Price

£568.00

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