Catalogue Number: 3880-MSM1-P1-EQB
|Shelf Life:||2 years|
|Preservative:||BSA and Azide|
|Type:||Monoclonal Primary Antibody|
|Alias:||k19; k1cs; Keratin 19 Keratin Type i 40kD; krt19; anti-k19 antibody; anti-k1cs antibody; anti-Keratin 19 Keratin Type i 40kD antibody; anti-krt19 antibody|
|Shipping Condition:||Blue Ice|
|Immunogen:||Human breast cancer MCF-7 cells|
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
This MAb reacts with the rod domain of human cytokeratin-19 (CK19), a polypeptide of 40kDa. Its epitope maps between amino acid 312-335. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.