Cytokeratin 19 Anti-Human Monoclonal [Clone A53-B/A2.26]

Catalogue Number: 3880-MSM1-P1-EQB

Manufacturer:Enquire Bioreagents
Shelf Life:2 years
Preservative:BSA and Azide
Physical state:Liquid
Type:Monoclonal Primary Antibody
Alias:k19; k1cs; Keratin 19 Keratin Type i 40kD; krt19; anti-k19 antibody; anti-k1cs antibody; anti-Keratin 19 Keratin Type i 40kD antibody; anti-krt19 antibody
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name: Mouse
Clone: A53-B/A2.26
Isotype: IgG2a, kappa
Immunogen: Human breast cancer MCF-7 cells

Additional Text

Molecular Weight

40kDa

Concentration

200ug/ml

Gene Symbol

KRT19

Hu-Chromosome Location

17q21.2

Additional application information

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.

Specificity

This MAb reacts with the rod domain of human cytokeratin-19 (CK19), a polypeptide of 40kDa. Its epitope maps between amino acid 312-335. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.