Anti-Bcl-2 Monoclonal Antibody (Clone: Bcl-2-100)

Catalogue Number: 39-1004-ABO

Manufacturer:Abeomics
Shelf Life:12 months
Type:Monoclonal Primary Antibody - Unconjugated
Alias:Apoptosis regulator Bcl-2; Bcl2; Bcl-2
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name: Mouse
Clone: Bcl-2-100
Isotype: IgG1
Immunogen: Synthetic peptide corresponding to residues 41-54 of the bcl-2 protein, conjugated to thyroglobulin.
Application: ICC, IHC-P, WB, IHC-Fr

Description

Description: Immunoreactive BCL2 protein in the neoplastic cells of almost all follicular lymphomas whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t(14;18) translocation expressed detectable levels of BCL2 protein, regardless of whether the breakpoint was located in or at a distance from the BCL2 gene. Overexpression of BCL2 blocks the apoptotic death of a pro-B-lymphocyte cell line.

Additional Text

Gene Name

BCL2

Gene ID

24224

Uniprot ID

P49950

Antibody Clonality

Monoclonal

Application Notes

Western blot : 1-2µg/ml; Immunohistochemistry(Paraffin-embedded Section) : 0.4-1µg/ml; Immunohistochemistry(Frozen Section) : 0.4-1µg/ml; Immunocytochemistry : 1µg/ml