CD335 (NKp46, Natural Cytotoxicity Triggering Receptor 1, NCR1) (APC)
Catalogue Number: 397017-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests |
| Host name: | Mouse |
| Clone: | VIV-KM1 |
| Isotype: | IgG1 |
| Immunogen: | Fusion protein corresponding to extracellular region of porcine CD335. |
| Application: | FC |
Description
Description: CD335, also known as NKp46 and natural cytotoxicity triggering receptor 1 (NCR1), a member of the natural cytotoxicity receptor (NCR) family. CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor and is involved in the control of viral infection and tumor development. Until recently little has been known about porcine and veterinary NK cells. CD335 is expressed by human natural killer cells and the development of monoclonal antibodies to bovine CD335 and sheep CD335 have enabled researchers to identify and better understand ruminant NK cells. This is the first monoclonal developed to specifically identify porcine CD335 and provides a reagent to facilitate a better understanding of the porcine immune system and aid in the understanding of the role of NK cells in host pathogen defense. Studies have shown that, within the porcine, CD335 is not universally expressed by all NK cells and that expression of this marker on NK cells may be influenced by cytokine production.
Additional Text
Purification
Protein A purified
Antibody Clonality
Monoclonal
397017 Datasheet
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