F4/80 (Epidermal Growth Factor TM7, Gpf480) (FITC)
Catalogue Number: 397071-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 25 ug, 500 ug |
| Host name: | Rat |
| Clone: | Cl:A3-1 |
| Isotype: | IgG2b |
| Immunogen: | Thioglycollate stimulated peritoneal macrophages from C57BL/6 mice. |
| Application: | FC, IF |
Description
Description: Expression of F4/80 is heterogeneous and is modulated during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans cells, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 antigen is also expressed on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not been fully determined but a role for F4/80 in the generation of efferent CD8+ve regulatory T cells is proposed. F4/80 modulates cytokine levels released in response to Listeria monocytogenes.
Additional Text
Uniprot ID
Q61549
Purification
Protein G purified
Gene ID
13733
Gene Name
ADGRE1
Antibody Clonality
Monoclonal
397071 Datasheet
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