Varicella Zoster Virus, Nucleocapsid (VZV)

Catalogue Number: 497285-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	22G1
Isotype:	IgG
Immunogen:	VZV Ellen Strain from BSC-1 cells
Application:	IF, IP, IHC

Overview
Datasheets

Description

Description: Varicella zoster virus (VZV) is one of eight herpes viruses known to infect humans and other vertebrates. It commonly causes chicken-pox in children and adults and herpes zoster (shingles) in adults and rarely in children. As with the other herpesviruses, VZV causes both acute illness and lifelong latency. Before vaccination became widespread, acute primary infection (varicella or "chickenpox") was common during childhood--especially in temperate climates. Primary infection is much less common in recent years as a result of childhood vaccination, but still may occur in unvaccinated individuals and in instances of vaccine failure. Varicella usually is a benign and self-limiting illness, but can be more severe in adults and in individuals with cellular immunodeficiency. These individuals are at much higher risk of pneumonia and disseminated disease with visceral involvement. Zoster typically presents as a painful, localized cutaneous eruption occurring along 1 or more contiguous dermatomes. As with varicella, zoster usually is self-limited in the immunocompetent host, but immunocompromised persons are at risk of more severe illness with cutaneous or visceral dissemination. Pain is a frequent complication of zoster, and pain that persists following complete healing of cutaneous lesions, referred to as post-therapeutic neuralgia, can be debilitating and difficult to control. VZV genome is a linear duplex DNA molecule, a laboratory strain has 124 Kb. VZV virons are spherical and 180-200nm in diameter. Their lipid envelope encloses the 100nm nucleocapsid of 162 hexameric and pentameric capsomeres arranged in an icosahedral form. VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV; however, there is no equivalent of HSV gD. There are at least five clades of this virus. Clades 1 and 3 include European/North American strains; clade 2 are Asian strains, especially from Japan; and clade 5 appears to be based in India. Clade 4 includes some strains from Europe but its geographic origins need further clarification. Varivax (Merck) is a chickenpox vaccine for children, adolescents and adults. Zostavax is a more concentrated formulation of the Varivax vaccine, designed to elicit an immune response in older adults whose immunity to VZV wanes with advancing age.

Additional Text

Purification

Protein G purified

Antibody Clonality

Monoclonal

497285 Datasheet

Price

£741.00

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