CD14 (APC)
Catalogue Number: 516218-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | monocyte differentiation antigen CD14|myeloid cell-specific leucine-rich glycoprotein |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests |
| Host name: | Mouse |
| Clone: | MEM-18 |
| Isotype: | IgG1 |
| Immunogen: | A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria. |
| Application: | FC |
Description
Description: CD14 is a 55kD GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where it serves as a multifunctional lipopolysaccharide receptor. It is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
Additional Text
Gene Name
CD14
Gene ID
929
Uniprot ID
P08571
Antibody Clonality
Monoclonal
Purification
Size-exclusion Chromatography
516218 Datasheet
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