PD-L1, Neutralizing (Biotin)
Catalogue Number: 544383-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Human |
| Clone: | 20E14 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant protein corresponding to human PD-L1, fused to Avi-Tag at C-terminal, expressed in HEK293 cells. |
| Application: | ELISA, WB |
Description
Description: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PDCD-1 that mediate inhibitory signals from the APC. PDCD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform. PDL-1 antibody has no cross-reactivity to PDL-2.
Additional Text
Gene Name
CD274
Uniprot ID
Q9NZQ7
Gene ID
29126
Purification
Protein A purified
Antibody Clonality
Monoclonal
544383 Datasheet
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