TIM-3 (PE)
Catalogue Number: 544411-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Human |
| Clone: | 20E16 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant protein corresponding to human TIM-3, expressed in HEK293 cells. |
| Application: | FC, IF |
Description
Description: T-cell immunoglobulin mucin 3, a transmembrane glycoprotein and member of the immunoglobulin superfamily, is preferentially expressed by differentiated CD4+ Th1 cells and CD8+ Tc1 (cytotoxic) cells, but not by CD4+ Th2 cells or CD8+ Tc2 cells. Tim-3 acts as a negative regulator of Th1-mediated inflammatory diseases including GVHD, type I diabetes, and EAE (experimental autoimmune encephamyelitis), promotes immunological tolerance, and is a receptor for galectin-9, shown to induce cell death of Th1 cells in vitro. Tim-3 is also involved in the regulation of macrophage activation, acts as a phagocytic receptor, and has been shown to recognize apoptotic cells via the IgV domain. Studies have shown Tim-3 significantly inhibits the efficient phagocytosis of apoptotic cells by PEMs (peritoneal exudate Mac1+ cells) ( Nakayama et al. 2009).
Additional Text
Gene Name
HAVCR2
Uniprot ID
Q8TDQ0
Gene ID
84868
Purification
Protein A purified
Antibody Clonality
Monoclonal
544411 Datasheet
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