Fibronectin (Cellular)
Catalogue Number: 590184-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | DH1 |
| Isotype: | IgG1 |
| Immunogen: | Purified fibronectin from A8387 fibrosarcoma cells. |
| Application: | ICC, WB |
Description
Description: Fibronectins are high molecular weight, disulphide-linked, dimeric cell adhesion glycoproteins found in basement membranes and in the interstitial connective tissue matrix. A single fibronectin gene is subject to alternative splicing in a cell-type-, development- and age-regulated manner which gives rise to multiple molecular forms. In addition to their prominent role in adhesion, fibronectins have been reported to mediate various aspects of cellular interaction, including migration during development and wound-healing, haemostasis, and the regulation of cell growth and differentiation. Cellular fibronectins (cFn) are found in low amounts in normal human plasma and tissues, but they are abundant in the plasma of carcinoma patients and in the stroma of various carcinomas. In contrast, a soluble form of fibronectin produced by hepatocytes is readily detectable in plasma and becomes deposited in pericellular matrices and within tissues. This form of fibronectin, referred to as 'plasma fibronectin' (pFn), differs from cFn by the absence of an aa sequence, known as extra domain A1.
Additional Text
Gene Name
FN1
Gene ID
2335
Uniprot ID
P02751
Purification
Protein A purified
Antibody Clonality
Monoclonal
590184 Datasheet
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