PDI (Protein Disulfide Isomerase)
Catalogue Number: 590429-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Mouse |
| Clone: | 1D3 |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of rat PDI. |
| Application: | ICC, IF, WB, IHC |
Description
Description: The mammalian protein disulfide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulfide bonds. PDI, an abundant protein of the ER (> 400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing and one domain lacking a redox-active-Cys-X-X-Cys-tetrapeptide (1). In addition to their roles as redox catalysts and isomerases, PDI proteins have other functions such as peptide binding, cell adhesion and perhaps chaperone activities. Platelet surface thiols and disulfides play an important role in platelet responses. Catalytically active PDI is found on platelet surfaces where it has been demonstrated to mediate platelet aggregation and secretion possible by reducing disulfide bonds thus leading to exposure of fibrinogen receptors in platelets.
Additional Text
Gene Name
P4HB
Purification
Protein G purified
Uniprot ID
P04785
Gene ID
25506
Antibody Clonality
Monoclonal
590429 Datasheet
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