CD54 (ICAM-1, Intercellular Adhesion Molecule 1, Human Rhinovirus Receptor, Precursor, BB2, Major Group Rhinovirus Receptor, P3.58) (Biotin)
Catalogue Number: 590557-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests |
| Host name: | Mouse |
| Clone: | 15.2 |
| Isotype: | IgG1, kappa |
| Immunogen: | Rheumatoid synovial cells and human monocytes |
| Application: | ELISA, FC, ICC, IP, WB, NT |
Description
Description: CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It exhibits a wide tissue distribution being expressed on both hematopoietic and non-hematopoietic cells. ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation. Expression on endothelium and other non-hematopoietic cells is strongly upregulated by inflammatory mediators. The ligands of CD54 are CD11a/LFA-1α and CD11b/Mac-1α. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels particularly in areas of inflammation. CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation presumably by enhancing interactions between T cells and APC.
Additional Text
Gene Name
ICAM1
Gene ID
3383
Uniprot ID
P05362
Purification
Purified
Antibody Clonality
Monoclonal
590557 Datasheet
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