LAG-3 Single Domain (LAG3)
Catalogue Number: 590603-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Llama |
| Clone: | 2A11 |
| Isotype: | |
| Immunogen: | Recombinant protein corresponding to aa23-434 from the extracelluar domain of human LAG3. |
| Application: | ELISA, FC, IF, IHC |
Description
Description: The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.
Additional Text
Gene Name
LAG3
Gene ID
3902
Uniprot ID
P18627
Purification
Affinity Purified
Accession Number
NP_002277
Antibody Clonality
Monoclonal
590603 Datasheet
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