Cytomegalovirus Phosphoprotein 65 (FITC)

Catalogue Number: 592366-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	23G6
Isotype:	IgG1
Immunogen:
Application:	IF, FLISA

Overview
Datasheets

Description

Description: Human Cytomegalovirus (HCMV) is an enveloped, double stranded DNA virus that belongs to the family Herpesviridae. The human CMV virus is ubiquitous and HCMV infection is globally widespread. The virus can be transmitted through direct contact with infected bodily fluids or though contact with virus infected transplant and transfusion material. Human CMV can also be transferred in utero from mother to fetus during pregnancy resulting in congenital HCMV infection of the newborn. Individuals can be re-infected by the same strain or by a different strain of HCMV. Once infected the virus remains latent in an individual and may reactivate later in life. In developed countries, 50 to 70% of all adults are thought to be HCMV sero-positive. Reports suggest that HCMV sero-prevalence increases with age, ethnicity, low socioeconomic status and sexuality. In healthy adults and children, HCMV infection is self-limiting with most cases being asymptomatic or presenting with mild, non-specific or mononucleosis-like symptoms. However, HCMV can cause severe clinical disease in immunocompromised patients. Congenital HCMV infection can lead to birth defects such as blindness, deafness, mental impairment, epilepsy and microcephaly. Human CMV is composed of a capsid containing the DNA genome, a tegument layer, and an envelope. It has the largest genome of any known human virus encoding numerous glycoproteins. HCMV proteins, localised in the tegument, play important roles in all stages of the viral life cycle and are potential targets for antiviral therapy. The phosphoprotein 65 (pp65) encoded by HCMV UL83, is the most abundant tegument protein and a major component of HCMV virions. pp65 is a target of the host's immune response and is responsible for modulating the host immune response to HMCV during an infection (Tomtishen, JP).

Additional Text

Purification

Purified

Antibody Clonality

Monoclonal

592366 Datasheet

Price

£581.00

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