S6 Ribosomal Protein, phosphorylated (Ser240/244)
Catalogue Number: 592412-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | D68F8 |
| Isotype: | IgG |
| Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Ser240 and Ser244 of human ribosomal protein S6. Species sequence homology: porcine and chicken |
| Application: | FC, ICC, IF, WB, IHC |
Description
Description: To effectively promote growth and cell division in a sustained manner, growth factors and mitogens must upregulate translation. Growth factors and mitogens induce the activation of p70 S6 kinase, which in turn phosphorylates the S6 ribosomal protein. Phosphorylation of S6 correlates with an increase in translation, particularly of mRNAs with an oligopyrimidine tract in their 5' untranslated regions. This group of mRNAs (5'TOP) encodes proteins involved in cell cycle progression and proteins that are part of the translational machinery, such as ribosomal proteins and elongation factors. The main in vivo S6 ribosomal protein phosphorylation sites, including Ser235, Ser236, Ser240 and Ser244, are located within a 19 amino acid region in the S6 carboxy-terminus.
Additional Text
Gene ID
6194
Gene Name
RPS6
Uniprot ID
P62753
Modification
Phosphorylated, Ser240
Purification
Purified
Antibody Clonality
Monoclonal
592412 Datasheet
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