IGF-I Receptor beta (Insulin-Like Growth Factor I Receptor beta, IGF1Rb)
Catalogue Number: 592429-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | D23H3 |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide corresponding to residues near the carboxy terminus of human IGF-I receptor beta |
| Application: | FC, ICC, IF, IP, WB |
Description
Description: Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).
Additional Text
Gene Name
IGF1R
Gene ID
3480
Uniprot ID
P08069
Purification
Purified
Antibody Clonality
Monoclonal
592429 Datasheet
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