SUMO-1 Anti-Human and Rat Monoclonal [Clone SUMO1/1188]

Catalogue Number: 7341-MSM2-P1-EQB

Manufacturer:Enquire Bioreagents
Shelf Life:2 years
Preservative:BSA and Azide
Physical state:Liquid
Type:Monoclonal Primary Antibody
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name: Mouse
Clone: SUMO1/1188
Isotype: IgG1, kappa
Immunogen: Recombinant human SUMO1 protein

Additional Text

Hu-Chromosome Location

2q33.1

Gene Symbol

SUMO1

Concentration

200ug/ml

Additional application information

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.

Molecular Weight

11.5kDa (Monomer); 90kDa (Heteromer)

Specificity

This MAb is specific to SUMO-1 and shows no cross-reaction with either SUMO-2 or SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1 protein localizes to the nuclear membrane.