Creatinine Colorimetric Detection Kit, 2x96 Wells, "RUO"

Catalogue Number: 74-CRNHU-E02-ALP

Manufacturer:	Alpco Diagnostics
Type:	Detection Kit
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	2 x 96 Wells
Host name:
Clone:
Isotype:
Immunogen:
Range:	0.31 - 20 mg/dL
Sensitivity:	0.042 mg/dL
Sample type:	Urine
Sample size:	25 µL
Application:	IA

Overview
Datasheets

Description

Description: Creatinine (2-amino-1-methyl-5H-imadazol-4-one) is a metabolite of phosphocreatine (p-creatine), a molecule used as a store for high-energy phosphate that can be utilized by tissues for the production of ATP1. Creatine either comes from the diet or is synthesized from the amino acids arginine, glycine, and methionine. This occurs in the kidneys and liver, although other organ systems may be involved and species-specific differences may exist (2). Creatine and p-creatine are converted non-enzymatically to the metabolite creatinine, which diffuses into the blood and is excreted by the kidneys. In vivo, this conversion appears to be irreversible and in vitro it is favored by higher temperatures and lower pH2. Creatinine forms spontaneously from p-creatine3, and under normal conditions, its formation occurs at a relatively constant rate. Intra-individual variation of creatinine levels is <15% from day to day, making it a useful marker for normalizing levels of other molecules found in urine. Altered creatinine levels may be associated with conditions that result in decreased renal blood flow, such as diabetes and cardiovascular disease (4-6). See instructions for use for references.

Additional Text

Regulatory Statuses

Research Use Only. Not for Use in Diagnostic Procedures.

Short Description

Creatinine Colorimetric Detection Kit

Storage Note

store at 2-8C

74-CRNHU-E02 Protocol

Price

£517.00

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