ABIN-1 (A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation) (APC)
Catalogue Number: A0004-75A-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 6A2 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Synthetic peptide corresponding to the N-terminal region of the human, mouse and rat ABIN-1 protein. |
| Application: | ELISA, IP, WB |
Description
Description: A20-binding inhibitor of NFkB activation (ABIN-1) is involved in NFkB-dependent gene expression and plays an important role in numerous cellular processes including stress responses, inflammation and cell proliferation. ABIN-1 increases cell surface CD4 (T4) antigen expression, and it interacts with HIV-1 matrix protein and is packaged into virions. Overexpression of ABIN-1can .inhibit viral replication. ABIN-1 may also regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. ABIN-1 is strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain.
Additional Text
Specificity
Recognizes the ~80kD human ABIN-1 protein. Bands of unknown origin at ~180kD and >250kD were observed in Western Blots using HEK-293 cell lysates. Species Sequence Homology: mouse and rat 100%.
Purification
Protein A purified
Antibody Clonality
Monoclonal
A0004-75A-APC Datasheet
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