Beta-Sheet Breaker Peptide iAβ5

Catalogue Number: A1005-APE

Manufacturer:	Apexbio
Molecular Weight:	637.73
Molecular Formula:	C33H43N5O8
Physical state:	A solid
Type:	Peptide
Alias:	H2N-Leu-Pro-Phe-Phe-Asp-OH
Shipping Condition:	Blue Ice
Unit(s):	5 mg, 10 mg, 25 mg

Overview
Datasheets

Description

Description: Beta-Sheet Breaker Peptide iAβ5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models. Research showed that beta-sheet breaker peptide significantly reduces amyloid beta-protein deposition in vivo and completely blocks the formation of amyloid fibrils in a rat brain model of amyloidosis. Current evidence supports the notion that beta-amyloid deposits or Abeta intermediates may be responsible for the pathogenesis in Alzheimer's disease (AD) patients. Because of its inhibition of cerebral amyloid beta-protein deposition, Beta-Sheet Breaker Peptide seems to be an important target for Alzheimer's disease therapy.Ref:1. C. Soto, E.M. Sigurdsson, L. Morelli, R.A. Kumar, E.M. Castano, and B. Frangione, Nat. Med., 4, 822 (1998) (Original; Pharmacol.)2. MA Chacon, MI Barria, C Soto and NC Inestrosa. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits.

Additional Text

Storage Note

Store at -20°C

Short Description

Peptide which can inhibit amyloidogenesis

CAS Number

182912-74-9

Reagent:Smile String

N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O

Price

£51.00

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